DAPP1 Rabbit Polyclonal Antibody

CAT#: AP20333PU-N

DAPP1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of DAPP1 antibody (Cat.-No.: AP20333PU-N) in extracts from 293 cells.

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  Immunohistochemistry analyzes of DAPP1 antibody (Cat.-No.: AP20333PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of DAPP1 protein.
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Predicted Protein Size: ~32 kDa
• Gene Name: Homo sapiens dual adaptor of phosphotyrosine and 3-phosphoinositides 1 (DAPP1), transcript variant 1
• Database Link:
  Entrez Gene 26377 MouseEntrez Gene 27071 Human
• Background: B cell adapter molecule (BAM32) is also designated a dual adapter for phosphotyrosine and 3-phosphotyrosine, and 3-phosphoinositide (DAPP1) or B lymphocyte adapter protein. BAM32 is a B cell-associated adapter that is crucial for B cell antigen receptor signaling regulation. BAM32 interacts with Ptdlns and PLC γ2 and, upon B cell activation, the protein is phosphorylated on tyrosine residues. It is a mainly cytoplasmic protein that can translocate to the cell membrane after cell stimulation. BAM32, which contains one PH domain and one SH2 domain, is primarily expressed in placenta and lung tissues, but can also be detected in heart, liver, pancreas and brain.
• Synonyms: BAM32, HSPC066, DKFZp667E0716, hDAPP1

Reference Data

• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: B cell receptor signaling pathway