STAM2 Rabbit Polyclonal Antibody

CAT#: AP20340PU-N

STAM2 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of STAM2 antibody (Cat.-No.: AP20340PU-N) in extracts from NIH/3T3cells.

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  Immunohistochemistry analyzes of STAM2 antibody (Cat.-No.: AP20340PU-N) in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of STAM2 protein.
• Formulation: Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Predicted Protein Size: ~58 kDa
• Gene Name: Homo sapiens signal transducing adaptor molecule 2 (STAM2)
• Database Link:
  Entrez Gene 56324 MouseEntrez Gene 10254 Human
• Background: Cytokine stimulation of the IL-2 receptor leads to the tyrosine phosphorylation of a number of cellular proteins and to the induction of various transcription factors including c-Fos and c-Myc. The signal transducing adapter molecule, STAM, is speculated to play a role in c-Myc induction by various cytokines. STAM contains an SH3 (Src homology 3) motif as well as an immunoreceptor tyrosine-based activation (ITAM) motif, both of which appear to be required for c-Myc induction in response to IL-2 and GM-CSF. STAM associates with JAK3 and JAK2 via its ITAM region, and it is tyrosine phosphorylated by JAK3 and JAK2 after stimulation with IL-2 and GM-CSF, respectively. STAM2, also known as Hbp, is a protein that is highly related to STAM. Similar to STAM, STAM2 functions downstream of JAK kinases and can be phosphorylated in response to cytokines. Due to alternative splicing events, two isoforms of STAM2 exist, namely STAM2A and STAM2B.
• Synonyms: STAM-2, Signal transducing adapter molecule 2, Hrs-binding protein, HBP, STAM2A, STAM2B

Reference Data

• Protein Pathways: Endocytosis, Jak-STAT signaling pathway