TNFSF9 Rabbit Polyclonal Antibody

CAT#: AP20383PU-N

TNFSF9 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of 4-1BBL antibody. ) at 1/500 dilution: Lane 1: Hela cell lysate. Lane 2: sp2/0 cell lysate. Lane 3: Rat liver tissue lysate. Lane 4: H9C2 cell lysate.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human 4-1BBL.
• Specificity: This antibody detects endogenous levels of 4-1BBL protein.
  (region surrounding Arg69)
• Formulation: PBS, pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Immunoaffinity Chromatography
• Predicted Protein Size: ~ 26 kDa
• Gene Name: Homo sapiens tumor necrosis factor superfamily member 9 (TNFSF9)
• Database Link:
  Entrez Gene 8744 Human
• Background: CD137, also designated ILA and 4-1BB in mouse, belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. CD137 is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. Crosslinking of the CD137 ligand induces apoptosis in resting lymphocytes. In contrast, CD137 regulates peripheral monocyte survival by inducing a cytokine release profile, and is mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Soluble forms of CD137 are found in sera from patients with rheumatoid arthritis and may provide a negative control mechanism for immune responses.
• Synonyms: 4-1BB ligand, CD137L

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction