ROR alpha (RORA) Rabbit Polyclonal Antibody

CAT#: AP20414PU-N

ROR alpha (RORA) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of RORa antibody (Cat.-No.: AP20414PU-N) in extracts from HeLa cells.

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  Immunohistochemistry analyzes of RORa antibody (Cat.-No.: AP20414PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of RORα protein.
  (region surrounding Gly41)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 60 kDa
• Gene Name: Homo sapiens RAR related orphan receptor A (RORA), transcript variant 3
• Database Link:
  Entrez Gene 6095 Human
• Background: Retinoid related orphan receptor alpha (ROR alpha) is a NR1 Thyroid Hormone Like Receptor. To date, ROR alph,a bet,a and gamma subtypes have been discovered. ROR alpha has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons and results in the staggerer phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis.
• Synonyms: Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, NR1F1, RZRA

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors