MELK Rabbit Polyclonal Antibody
Other products for "MELK"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of MELK protein. (region surrounding asn449) |
Formulation | Phosphate buffered saline (PBS), pH~7.2 with 0.05% Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen. |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~75 kDa |
Gene Name | Homo sapiens maternal embryonic leucine zipper kinase (MELK), transcript variant 1 |
Database Link | |
Background | Maternal Embryonic Leucine Zipper Kinase (KIAA0175, HPK38) or MELK, a new member of the Snf1/AMPK family of kinases, encodes a protein with a kinase catalytic domain and a leucine zipper motif consisting of a periodic repetition of leucine residues at every seventh residue located within the N-terminal catalytic domain. This motif has been observed in myriad DNAbinding proteins and is presumed to be involved in protein-DNA interactions, and potentially protein-protein interactions. Research predicts that the gene product of MELK plays a role in the signal transduction events in the egg and early embryo. Mouse and human MELK proteins share 95% sequence identity in the kinase domain and northern blot analysis in mouse indicates that MELK expression is restricted to spermatogonia in the testis and to oocytes in the ovary. |
Synonyms | Maternal embryonic leucine zipper kinase, KIAA0175, hMELK |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
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