TSTD3 (TAF-I beta) Rabbit Polyclonal Antibody

CAT#: AP20445PU-N

TSTD3 (TAF-I beta) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of TAF I p48 antibody (Cat.-No.: AP20445PU-N) in extracts from HeLa cells.

• 

  Immunohistochemistry (IHC) analyzes of TAF I p48 antibody (Cat.-No.: AP20445PU-N) in paraffin-embedded human brain carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of TAF I p48 protein.
  (region surrounding Arg318)
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 53 kDa
• Gene Name: Homo sapiens SET nuclear proto-oncogene (SET), transcript variant 1
• Database Link:
  Entrez Gene 307947 RatEntrez Gene 100130890 Human
• Background: For gene transcription governed by RNA polymerase I, the human transcription factor SL1 (mouse TIF-IB) directs the assembly of initiation complexes at the prompter. Like TFIID, which directs transcription by RNA polymerase II, SL1/TIF-IB contains the TATA-binding protein (TBP) and a set of TBP-associated factors (TAFs). The three TAF I subunits, hTAF I p110, hTAF I p63 and hTAF p48 (or mouse TAF I p95, TAF I p68 and TAF I p48) are all integral components of SL1/TIF-IB. The mutually exclusive binding of either TAF I or TAF II subunits to TBP is believed to direct the formation of promoter and RNA polymerase-specific complexes.
• Synonyms: I-2PP2A, TAF-I, PHAPII, IGAAD

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Stem cell - Pluripotency