SHARP1 (BHLHE41) Rabbit Polyclonal Antibody

CAT#: AP20458PU-N

SHARP1 (BHLHE41) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of DEC2 antibody (. in extracts from RAW264.7 cells.

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  Immunohistochemistry analysis of DEC2 antibody. in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide around Lys31 of Human BHLHE41 / BHLHB3
• Specificity: This antibody detects endogenous levels of DEC2 protein.
  (region surrounding Lys31)
• Formulation: PBS, pH~7.3
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Predicted Protein Size: ~ 50 kDa
• Gene Name: Homo sapiens basic helix-loop-helix family member e41 (BHLHE41)
• Database Link:
  Entrez Gene 79362 MouseEntrez Gene 117095 RatEntrez Gene 79365 Human
• Background: Human DEC1 is a 412 amino acid, basic helix-loop-helix (bHLH) containing protein that is involved in the control of proliferation and/or differentiation of several cell types including nerve cells, fibroblasts and chondrocytes. The bHLH region of DEC1 is structurally similar to the bHLH regions of the mammalian HES family, Drosophila hairy, and Enhancer of split m7. DEC1 is a novel direct target for cAMP in a wide range of cells, and is involved in the control of gene expression in cAMP-activated cells. DEC2, also known as SHARP1, is highly expressed in skeletal muscle and brain. The gene encoding human DEC2 maps to chromosome 12p11.23-p12.1. DEC1 and DEC2 play a role in regulating the mammalian molecular clock by suppressing the transcription of specific clock genes. Both DEC1 and DEC2 are detected in the suprachiasmimc nucleus in a circadian fashion. Brief light impulses induce the expression of DEC1 in a phase-dependent manner.
• Synonyms: DEC2, SHARP1, SHARP-1

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Circadian rhythm - mammal