BUB3 Rabbit Polyclonal Antibody
Other products for "BUB3"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | Western blot: 1/500 - 1/1000. Immunohistochemistry on paraffin sections: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 251-300 of Human BUB3. |
Specificity | This antibody detects endogenous levels of Bub3 protein. (region surrounding His274) |
Formulation | Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction ( > 95% pure by SDS-PAGE) |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~ 40 kDa |
Gene Name | Homo sapiens BUB3, mitotic checkpoint protein (BUB3), transcript variant 2 |
Database Link | |
Background | The mitotic checkpoint protein Bub3 appears to be essential during normal mitotic progression, preventing premature sister chromatid separation, missegreation and aneuploidy. Bub3 is also important during G2 and early mitosis stages, promoting normal mitotic entry. Loss of Bub3 function causes slower progression through prophase, apparently due to mitotic cyclins A and B not being accumulated. |
Synonyms | BUB3L; hBUB3 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Cell cycle |
Documents
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