TNFSF12-TNFSF13 Rabbit Polyclonal Antibody

CAT#: AP20513PU-N

TNFSF12-TNFSF13 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of TWEAK antibody in extracts from COLO cells.

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  Immunohistochemistry (IHC) analyzes of TWEAK antibody in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
  IF: 1/50-1/200
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 51-100 of Human TWEAK.
• Specificity: This antibody detects endogenous levels of TWEAK protein.
  (region surrounding Pro73)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 27 kDa
• Gene Name: Homo sapiens tumor necrosis factor superfamily member 12 (TNFSF12), transcript variant 1
• Database Link:
  Entrez Gene 21944 MouseEntrez Gene 407977 Human
  UniProt ID O43508
• Background: TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. It is widely expressed, has high constitutive expression in heart placent,a lung, muscle, kidney, pancreas, and HUVEC. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TWEAK can induce apoptosis via multiple pathways of cell death in a cell type specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.
• Synonyms: APO3 ligand, APO3L, DR3LG

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction