Cathepsin E (CTSE) Rabbit Polyclonal Antibody

CAT#: AP20573PU-N

Cathepsin E (CTSE) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Cathepsin E antibody in extracts from HUVECcells.

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  Western blot (WB) analysis of Cathepsin E antibody at 1/500 dilution. Lane 1: MCF-7 cell lysate. Lane 2: Mouse lung tissue lysate. Lane 3: Rat lung tissue lysate.

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  Immunohistochemistry (IHC) analyzes of Cathepsin E antibody in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acids 260-310 of Human Cathepsin E.
• Specificity: This antibody detects endogenous levels of Cathepsin E protein.
  (region surrounding Ile292)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Predicted Protein Size: ~ 48 kDa
• Gene Name: Homo sapiens cathepsin E (CTSE), transcript variant 1
• Database Link:
  Entrez Gene 13034 MouseEntrez Gene 25424 RatEntrez Gene 1510 Human
• Background: Cathepsin E is an intracellular aspartic protease of the pepsin family, which is structurally highly homologous to the lysosomal aspartic protease cathepsin D. Cathepsin E is less abundant than Cathepsin D and has a more limited distribution, which includes lymphoid tissues, gastrointestinal tract tissue, blood cells, microglia and activated B lymphocytes. It is not expressed in resting B lymphocytes.Cathepsin E may have a role in immune function. It is most likely involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. It may also play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
• Synonyms: CTSE

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Lysosome