PAX8 Rabbit Polyclonal Antibody

CAT#: AP20584PU-N

PAX8 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Pax-8 antibody (Cat.-No.: AP20584PU-N) in extracts from HT-29 cells.

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  Immunohistochemistry (IHC) analyzes of Pax-8 antibody (Cat.-No.: AP20584PU-N) in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Pax-8 protein.
  (region surrounding Asp194)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 60 kDa
• Gene Name: Homo sapiens paired box 8 (PAX8), transcript variant PAX8A
• Database Link:
  Entrez Gene 18510 MouseEntrez Gene 81819 RatEntrez Gene 7849 Human
• Background: This protein is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells.
• Synonyms: Pax-8

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Thyroid cancer