CNPase (CNP) Rabbit Polyclonal Antibody

CAT#: AP20586PU-N

CNPase (CNP) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of CNPase antibody (Cat.-No.: AP20586PU-N) in extracts from HUVEC cells.

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  Immunohistochemistry (IHC) analyzes of CNPase antibody (Cat.-No.: AP20586PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of CNPase protein.
  (region surrounding Ala108)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 48 kDa
• Gene Name: Homo sapiens 2',3'-cyclic nucleotide 3' phosphodiesterase (CNP), transcript variant 1
• Database Link:
  Entrez Gene 12799 MouseEntrez Gene 25275 RatEntrez Gene 1267 Human
  UniProt ID P09543
• Background: CNPase (2',3'-Cyclic Nucleotide 3'-Phosphodiesterase) exists in two forms: 46kDa (CNP1) and 48kDa (CNP2). It is expressed at high levels by oligodendrocytes in the central nervous system and by Schwann cells in the peripheral nervous system and is virtual absent in other cell types. CNPase activity is decreased in demyelinating diseases such as multiple sclerosis. CNPase gene is localized to chromosome 17q21, very near the BRCA 1 familial breast cancer gene.
• Synonyms: CNP, CNP1, Oligodendrocyte Marker