MYD88 Rabbit Polyclonal Antibody

CAT#: AP20639PU-N

MYD88 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of MyD88 antibody (Cat.-No.: AP20639PU-N) in extracts from COLO cells.

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  Immunohistochemistry analyzes of MyD88 antibody (Cat.-No.: AP20639PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of MyD88 protein.
  (region surrounding Val220)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Predicted Protein Size: ~35 kDa
• Gene Name: Homo sapiens myeloid differentiation primary response 88 (MYD88), transcript variant 2
• Database Link:
  Entrez Gene 17874 MouseEntrez Gene 301059 RatEntrez Gene 4615 Human
• Background: Interleukin-1 (IL-1)-induced activation of the NFκB pathway is mediated through the IL-1 receptor and the subsequent phosphorylation of IL-1 receptorassociated kinase (IRAK). The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophili,a and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFκB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.
• Synonyms: Myeloid differentiation primary response protein MyD88

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Apoptosis, Toll-like receptor signaling pathway