Livin (BIRC7) Rabbit Polyclonal Antibody

CAT#: AP20649PU-N

Livin (BIRC7) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of ML-IAP antibody (Cat.-No.: AP20649PU-N) in extracts from COLO cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of ML-IAP protein.
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 21 kDa
• Gene Name: Homo sapiens baculoviral IAP repeat containing 7 (BIRC7), transcript variant 2
• Database Link:
  Entrez Gene 79444 Human
• Background: Inhibitor of apoptosis proteins (IAPs) contain conserved, unique aminoterminal baculovirus IAP repeats (BIRs) and usually a C-terminal RING finger domain. Immunoprecipitation and Western blot analysis indicate that ML-IAP, also known as melanoma inhibitor of apoptosis protein, kidney inhibitor of apoptosis protein (KIAP), livin or BIRC7, binds to caspase-3, -7, and -9, but only inhibits caspase-9. Additionally, ML-IAP physically interacts with SMAC through its BIR domain with a very high affinity and this interaction is very specific. The gene which encodes ML-IAP maps to human chromosome 20q13.3. There is controversy regarding the localization of this protein and its involvement in apoptosis, but it has been suggested that ML-IAP may play a complex role in the regulation of apoptosis.
• Synonyms: KIAP, MLIAP, RNF50

Reference Data

• Protein Families: Druggable Genome