Livin (BIRC7) Rabbit Polyclonal Antibody
Other products for "BIRC7"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western blot: 1/500 - 1/1000. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of ML-IAP protein. |
Formulation | Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE) |
Predicted Protein Size | ~ 21 kDa |
Gene Name | Homo sapiens baculoviral IAP repeat containing 7 (BIRC7), transcript variant 2 |
Database Link | |
Background | Inhibitor of apoptosis proteins (IAPs) contain conserved, unique aminoterminal baculovirus IAP repeats (BIRs) and usually a C-terminal RING finger domain. Immunoprecipitation and Western blot analysis indicate that ML-IAP, also known as melanoma inhibitor of apoptosis protein, kidney inhibitor of apoptosis protein (KIAP), livin or BIRC7, binds to caspase-3, -7, and -9, but only inhibits caspase-9. Additionally, ML-IAP physically interacts with SMAC through its BIR domain with a very high affinity and this interaction is very specific. The gene which encodes ML-IAP maps to human chromosome 20q13.3. There is controversy regarding the localization of this protein and its involvement in apoptosis, but it has been suggested that ML-IAP may play a complex role in the regulation of apoptosis. |
Synonyms | KIAP, MLIAP, RNF50 |
Reference Data | |
Protein Families | Druggable Genome |
Documents
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