NF2 Rabbit Polyclonal Antibody

CAT#: AP20757PU-N

NF2 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of Merlin antibody (Cat.-No.: AP20757PU-N) in extracts from HuvEc cells.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Merlin protein.
  (region surrounding Thr512)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~70 kDa
• Gene Name: Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 1
• Database Link:
  Entrez Gene 18016 MouseEntrez Gene 25744 RatEntrez Gene 4771 Human
• Background: Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility. Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.
• Synonyms: Neurofibromin-2, NF2, SCH, Schwannomin, Schwannomerlin

Reference Data

• Protein Families: Druggable Genome