Activin Receptor Type IIA (ACVR2A) Rabbit Polyclonal Antibody

CAT#: AP20763PU-N

Activin Receptor Type IIA (ACVR2A) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of ACTR-IIA antibody (Cat.-No.: AP20763PU-N) in extracts from rat kidney cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 30-80 of Human ACTR-IIA.
• Specificity: This antibody detects endogenous levels of ACTRIIA protein.
  (region surrounding His59)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 48 kDa
• Gene Name: Homo sapiens activin A receptor type IIA (ACVR2A), transcript variant 2
• Database Link:
  Entrez Gene 11480 MouseEntrez Gene 29263 RatEntrez Gene 92 Human
  UniProt ID P27037
• Background: Members of the transforming growth factor beta superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (ACVR2A) or ACTRIIB (ACVR2B). Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation and morphogenesis in a dose dependent manner.
• Synonyms: ACTR-IIA, ACTRIIA, Activin A receptor type IIA

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway