MMP12 Rabbit Polyclonal Antibody

CAT#: AP20790PU-N

MMP12 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of MMP-12 antibody (Cat.-No.: AP20790PU-N) in extracts from HepG2 cells.

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  Immunohistochemistry (IHC) analyzes of MMP-12 antibody (Cat.-No.: AP20790PU-N) in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of MMP-12 protein.
  (region surrounding Asp411)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 48 kDa
• Gene Name: Homo sapiens matrix metallopeptidase 12 (MMP12)
• Database Link:
  Entrez Gene 4321 Human
• Background: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 (also designated macrophage metalloelastase) is produced in alveolar macrophages and degrades elastin. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders.
• Synonyms: Macrophage metalloelastase, HME, ME, Matrix metalloproteinase-12, MMP12, Macrophage elastase

Reference Data

• Protein Families: Druggable Genome, Protease