NF2 pSer518 Rabbit Polyclonal Antibody

CAT#: AP20869PU-N

NF2 pSer518 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of p-NF2 antibody (Cat.-No.: AP20869PU-N) in extracts from Jurkat IFN cells.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunofluorescence: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of p-NF2 protein only when phosphorylated at Ser518.
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 70 kDa
• Gene Name: Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 1
• Database Link:
  Entrez Gene 18016 MouseEntrez Gene 25744 RatEntrez Gene 4771 Human
  UniProt ID P35240
• Background: Neurofibromatosis type 2 (NF2) is a dominantly inherited disorder characterized by the occurance of bilateral vestibular schwannomas and other central nervous system tumors, including multiple meningiomas. NF2 occurs in about 1 of 40,000 live births. The NF2 gene is highly penetrant; NF2-affected individuals have a 95% chance of developing bilateral vestibular schwannomas. NF2 is distinct from NF1, which is characterized by an incidence of 1 in 4000, maps to chromosome 17 and encodes a protein designated neurofibromin, which is a large protein with a GAP domain. Genetic linkage studies of both sporadic and familial tumors suggest that NF2 is caused by inactivation of a tumor suppressor gene that maps on chromosome 22q12 and encodes a 595 amino acid protein whose function appears to be mediated by interaction with the cytoskeleton.
• Synonyms: Neurofibromin-2, NF2, SCH, Schwannomin, Schwannomerlin

Reference Data

• Protein Families: Druggable Genome