c Fos (FOS) Rabbit Polyclonal Antibody
Other products for "FOS"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Western blot: 1/500 - 1/1000. Immunohistochemistry on paraffin sections: 1/50 - 1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of c-Fos protein. (region surrounding Ser368) |
Formulation | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 15 mM sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity chromatography (> 95% (by SDS-PAGE) |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~ 62 kDa |
Gene Name | Homo sapiens Fos proto-oncogene, AP-1 transcription factor subunit (FOS) |
Database Link | |
Background | The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B, which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes. |
Synonyms | FOS, G0S7 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | B cell receptor signaling pathway, Colorectal cancer, MAPK signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway |
Documents
Product Manuals |
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