CNOT4 Rabbit Polyclonal Antibody

CAT#: AP21144PU-N

CNOT4 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of CNOT4 antibody (Cat.-No.: AP21144PU-N) in extracts from PC12 cells.

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  Immunohistochemistry (IHC) analyzes of CNOT4 antibody (Cat.-No.: AP21144PU-N) in paraffin-embedded human testis tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of CNOT4 protein.
  (region surrounding Glu95)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 52 kDa
• Gene Name: Homo sapiens CCR4-NOT transcription complex subunit 4 (CNOT4), transcript variant 2
• Database Link:
  Entrez Gene 53621 MouseEntrez Gene 312227 RatEntrez Gene 4850 Human
• Background: CNOT4 (CCR4 NOT transcription complex subunit 4) has intrinsic E3 ubiquitin ligase activity. Binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective. The CCR4-NOT complex functions as a global regulator of RNA polymerase II transcription.
• Synonyms: NOT4Hp, NOT4

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: RNA degradation