TSTA3 Rabbit Polyclonal Antibody

CAT#: AP21180PU-N

TSTA3 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of FX antibody (Cat.-No.: AP21180PU-N) in extracts from rat muscle cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of FX protein.
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 40 kDa
• Gene Name: Homo sapiens tissue specific transplantation antigen P35B (TSTA3), transcript variant 2
• Database Link:
  Entrez Gene 22122 MouseEntrez Gene 300036 RatEntrez Gene 7264 Human
• Background: GDP-L-fucose synthetase (FX protein), also designated Tissue-specific transplantation antigen P35B or GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, belongs to the fucose synthetase family. FX is a red cell NADP(H)- binding protein that is important in leukocyte adhesion and trafficking processes. The FX protein, together with GDP-mannose 4,6-dehydratase, can convert GDP-mannose to GDP-L-fucose by catalyzing the two-step epimerase and reductase reactions. GDP-L-fucose is the substrate of several fucosyltransferases that function in the expression of many glycoconjugates such as blood group ABH antigens and developmental adhesion antigens. Defects in the gene encoding for the FX protein cause leukocyte adhesion deficiency (LAD).
• Synonyms: GDP-L-fucose synthetase, SDR4E1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism, Metabolic pathways