Leptin Receptor (LEPR) (829-841) Goat Polyclonal Antibody

CAT#: AP22503PU-N

Leptin Receptor (LEPR) (829-841) goat polyclonal antibody, Aff - Purified

Product Images

Western Blot analysis of human brain lysate

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  Human Heart (formalin-fixed, paraffin-embedded) stained with LEPR antibody at 4 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Liver (formalin-fixed, paraffin-embedded) stained with LEPR antibody at 4 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: Peptide ELISA: 1/16000.
  Immunohistochemistry on Paraffin Sections: 4 µg/ml.
  Western Blot: 1-3 µg/ml.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide C-TQDDIEKHQSDAG from an internal region of human LEPR / Leptin Receptor (NP_002294.2; NP_001003679.1; NP_001003680.1).
  Epitope: aa829-841
• Specificity: This antibody detects CD295 / Leptin Receptor at aa 829-841.
  The antibody is expected to recognise all three reported isoforms (NP_002294.2; NP_001003679.1; NP_001003680.1).
• Formulation: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% Sodium Azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens leptin receptor (LEPR), transcript variant 3
• Database Link:
  Entrez Gene 3953 Human
• Background: LEPR / Leptin Receptor belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction.
• Synonyms: LEP-R, OB receptor, HuB219, LEPR, DB, OBR, OB-R

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction