Leptin Receptor (LEPR) (829-841) Goat Polyclonal Antibody
CAT#: AP22503PU-N
Leptin Receptor (LEPR) (829-841) goat polyclonal antibody, Aff - Purified
Other products for "LEPR"
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommended Dilution | Peptide ELISA: 1/16000. Immunohistochemistry on Paraffin Sections: 4 µg/ml. Western Blot: 1-3 µg/ml. |
Reactivities | Human |
Host | Goat |
Clonality | Polyclonal |
Immunogen | Synthetic peptide C-TQDDIEKHQSDAG from an internal region of human LEPR / Leptin Receptor (NP_002294.2; NP_001003679.1; NP_001003680.1). aa829-841 |
Specificity | This antibody detects CD295 / Leptin Receptor at aa 829-841. The antibody is expected to recognise all three reported isoforms (NP_002294.2; NP_001003679.1; NP_001003680.1). |
Formulation | Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% Sodium Azide State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Immunoaffinity chromatography |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens leptin receptor (LEPR), transcript variant 3 |
Database Link | |
Background | LEPR / Leptin Receptor belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. |
Synonyms | LEP-R, OB receptor, HuB219, LEPR, DB, OBR, OB-R |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction |
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