Aurora B (AURKB) (1-344) Sheep Polyclonal Antibody

CAT#: AP22823PU-N

Aurora B (AURKB) (1-344) sheep polyclonal antibody, Purified

Product Images

Human Skin (formalin-fixed, paraffin-embedded) stained with AURKB antibody at 10 ug/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Tonsil (formalin-fixed, paraffin-embedded) stained with AURKB antibody at 10 ug/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 0.2 µg/ml.
• Reactivities: Human
• Host: Sheep
• Clonality: Polyclonal
• Immunogen: AURKB antibody was raised against recombinant Human His(6)-Aurora B [residues 1-344] expressed in insect cells.
• Specificity: This antibody recognizes Aurora Kinase B (AURKB/ARK2) at aa 1-344.
• Formulation: PBS containing 0.09% Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 0.105 mg/ml
• Purification: Affinity Chromatography
• Gene Name: Homo sapiens aurora kinase B (AURKB), transcript variant 1
• Database Link:
  Entrez Gene 9212 Human
• Background: ARK2, an Aurora/IPL1-like protein kinase, functions in bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics, and chromosome condensation and cohesion. ARK2 has been shown to be physically associated with inner centromere protein (INCENP) during mitosis, and activated ARK2 has been shown to phosphorylate histone H3. The Ark2 gene has been mapped to 17p13.1, a region that is frequently deleted in tumors, and has been shown to be transcriptionally overexpressed in many tumor cell lines. Overexpression of ARK2 disrupts cleavage furrow formation without affecting nuclear division, often resulting in multinuclearity and polyploidy.
• Synonyms: Aurora-B, Aurora/IPL1-related kinase 2, STK-1, AURKB, AIK2, AIM1, ARK2, STK12

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Stem cell - Pluripotency