Integrin alpha 4 (ITGA4) Rabbit Polyclonal Antibody

CAT#: AP22982PU-N

Integrin alpha 4 (ITGA4) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of Integrin alpha 4 in rat spleen tissue lysate with Integrin alpha 4 antibody (AP22982PU-N) at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

• 

  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunofluorescence.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 0.5 - 1 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide (GNSAGPKSMEVSC) from (C-term) of human NDRG1
• Specificity: This antibody reacts to Integrin, Alpha 4 (antigen CD49D, Alpha 4 Subunit Of VLA-4 Receptor) (ITGA4).
• Formulation: PBS containing 0.02% sodium azide
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 1
• Database Link:
  Entrez Gene 16401 MouseEntrez Gene 311144 RatEntrez Gene 3676 Human
• Background: ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.
• Synonyms: Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Regulation of actin cytoskeleton