PAI1 (SERPINE1) (71-85) Goat Polyclonal Antibody

CAT#: AP23034PU-N

PAI1 (SERPINE1) (71-85) goat polyclonal antibody, Aff - Purified

Product Images

Staining of Human Liver lysate (35 ug protein in RIPA buffer) using PAI1 antibody. Primary incubation was 1 hour. Detected by chemiluminescence.

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  Formalin-Fixed, Paraffin-Embedded Human Prostate stained with PAI1 antibody at 2.5 ug/ml after heat-induced antigen retrieval.

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  Formalin-Fixed, Paraffin-Embedded Human Placenta stained with PAI1 antibody at 2.5 ug/ml after heat-induced antigen retrieval.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/32000.
  Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
  Western Blot: 0.1 - 0.3 µg/ml.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from internal region of Human PAI1 (NP_000593.1; NP_001158885.1)
• Specificity: This antibody detects SERPINE1 / PAI1 (Internal).
  It is expected to recognise both reported isoforms.
• Formulation: Tris saline buffer, pH 7.3
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Stabilizer: 0.5% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens serpin family E member 1 (SERPINE1)
• Database Link:
  Entrez Gene 5054 Human
• Background: PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.
• Synonyms: Serpin E1, PLANH1, Plasminogen Activator Inhibitor 1, PAI-1, PAI

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades, p53 signaling pathway