PDE4D (796-809) Goat Polyclonal Antibody

CAT#: AP23038PU-N

PDE4D (796-809) goat polyclonal antibody, Aff - Purified

Product Images

Western Blot Image: Antibody staining (1 ug/ml) of COS cell lysates (25 ug protein): transfected with Human PDE4D1 (1), transfected with Human PDE4D3 (2), untransfected (3). Primary incubation was 1 hour. Detected by chemiluminescence.

• 

  Immunohistochemistry Image: Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)

• 

  Immunohistochemistry Image: Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/128000.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 0.1 - 1 µg/ml.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from C-terminus of human PDE4D
• Specificity: This antibody detects PDE4D (C-term).
  It is expected to recognize all reported isoforms.
• Formulation: Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens phosphodiesterase 4D (PDE4D), transcript variant 1
• Database Link:
  Entrez Gene 5144 Human
• Background: Phosphodiesterase 4D, a cAMP-specific phosphodiesterase, has been shown to affect growth and fertility, functioning of pro-inflammatory immune cells, and cholinergic stimulation of the airway and consequently the development of hyperreactive disease states such as asthma. PDE4D activity is inhibited by rolipram. At least six splice variants have been reported. Recently PDE4D has been linked to stroke, possibly through atherosclerosis, which is the primary pathological process underlying ischemic stroke (Gretarsdottir et al. 2003).
• Synonyms: PDE4D, DPDE3, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, EC=3.1.4.17, DPDE3, PDE43

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Progesterone-mediated oocyte maturation, Purine metabolism