p27 KIP 1 (CDKN1B) (153-165) Goat Polyclonal Antibody

CAT#: AP23041PU-N

p27 KIP 1 (CDKN1B) (153-165) goat polyclonal antibody, Aff - Purified

Product Images

Western Blot Image: Antibody (0.1 ug/ml) staining of Human Prostate lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• 

  Immunohistochemistry Image: Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

• 

  Immunohistochemistry Image: Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/32000.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/32000, 0.1 - 0.3 µg/ml.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human CDKN1B
• Specificity: This antibody reacts to the internal region of CDKN1B / p27 Kip1.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity chromatography
• Gene Name: Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
• Database Link:
  Entrez Gene 1027 Human
• Background: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
• Synonyms: p27Kip1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer