RASSF1 (135-147) Goat Polyclonal Antibody

CAT#: AP23127PU-N

RASSF1 (135-147) goat polyclonal antibody, Aff - Purified

Product Images

Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Liver, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Bat, Bovine, Equine, Human, Porcine
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human RASSF1 / RASSF1A (NP_009113.3; NP_733830.1; NP_733831.1; NP_733832.1)
• Specificity: This antibody detects RASSF1 (Internal).
  It is expected to recognize reported isoforms A, C and D (NP_009113.3; NP_733831.1; NP_733832.1) .
• Formulation: Tris saline, pH 7.3 containing 0.02% sodium azide as preservative and 0.5% BSA as stabilizer
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens Ras association domain family member 1 (RASSF1), transcript variant A
• Database Link:
  Entrez Gene 11186 Human
• Background: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression.
• Synonyms: RASSF1A, RDA32, REH3P21, NORE2A

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Bladder cancer, Non-small cell lung cancer, Pathways in cancer