PLK1 (161-440) Rabbit Polyclonal Antibody

CAT#: AP23177PU-N

PLK1 (161-440) rabbit polyclonal antibody, Aff - Purified

Product Images

Sample (30 ug whole cell lysate). A:Raji. 7.5% SDS PAGE. PLK1 antibody diluted at 1:1000

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  Human Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 161 and 440 of Human PLK1
• Specificity: This antibody detects PLK1 at 161-440.
• Formulation: 0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store (in aliquots) at -20 °C. Dilute only prior to immediate use. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens polo-like kinase 1 (PLK1)
• Database Link:
  Entrez Gene 25515 RatEntrez Gene 5347 Human
• Background: PLK, a Polo type protein kinase, has been shown to function in mitosis. The mRNA is absent or expressed at very low levels during the G1 phase, begins to reaccumulate during the S phase, and reaches maximal levels during the G2/M phase. PLK1 may participate in targeting MPF to the nucleus during prophase and in regulating mitotic spindle function. These functions, in addition to its expression in proliferating cells, suggest that PLK1 has a role in cancer progression.
• Synonyms: Polo-like kinase 1, PLK-1, STPK13

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation