COX2 (PTGS2) (N-term) Rabbit Polyclonal Antibody

CAT#: AP23344PU-N

COX2 (PTGS2) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

AP23344PU-N COX2 antibody staining of Human Mammary Cancer.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 0.1-0.5 μg/ml.
  Immunohistochemistry on Paraffin Sections: 1-2 μg/ml by heat antigen treatement.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of Human COX-2
• Specificity: This antibody detects Cyclooxygenase 2 (N-term). No cross reactivity with other proteins.
• Formulation: 0.2mg Na₂HPO₄, 0.9mg NaCl
  State: Aff - Purified
  State: Lyophilized Ig fraction
  Stabilizer: 5mg BSA
  Preservative: 0.05mg Sodium Azide, 0.05 mg Thimerosal
• Reconstitution Method: Restore with 0.2 ml distilled water to a concentration of 500 μg/ml
• Purification: Immunoaffinity Chromatography
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens prostaglandin-endoperoxide synthase 2 (PTGS2)
• Database Link:
  Entrez Gene 19225 MouseEntrez Gene 29527 RatEntrez Gene 5743 Human
• Background: Cyclooxygenase (Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms,Cox-1 and Cox-2, have been identified. Cox-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis. This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina. And the glucocorticoid receptor suppression of COX-2 is also crucial for curtailing lethal immune activation, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases.
• Synonyms: Cyclooxygenase-2, PTGS2, COX2, PHS II, PGH synthase 2, PGHS-2, PGHS2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arachidonic acid metabolism, Pathways in cancer, Small cell lung cancer, VEGF signaling pathway