STAT1 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23359PU-N

STAT1 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemical analysis of paraffin-embedded human carcinoma ventriculi sections, staining STAT1 in cytoplasm, DAB chromogeniic reaction

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: At 1-2μg/ml with the appropriate system to detect stat1(P91) in cells and tissues.
  Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect stat1(P91)in formalin fixed and paraffin embedded tissues. Boiling the sections is required.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide mapping at the C-terminus of human stat1(P91)
• Specificity: This antibody detects STAT1 near C-term. No cross reactivity with other proteins.
• Formulation: 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 1.2% sodium acetate or neutral PBS. If 0.5ml of PBS is used, the antibody concentration will be 100μg/ml.
• Purification: Immunogen affinity purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens signal transducer and activator of transcription 1 (STAT1), transcript variant alpha
• Database Link:
  Entrez Gene 20846 MouseEntrez Gene 25124 RatEntrez Gene 6772 Human
• Background: Chen et al. (1998) determined the crystal structure of the DNA complex of a 67-kD core fragment of the STAT1 homodimer, lacking only the N-domain and the C-terminal transcriptional activation domain, at 2.9-angstrom resolution. Phosphorylation of Signal Transducer and Activator of transcription 1(STAT 1) was also decreased in rheumatoid arthritis lymphocytes. The transcription factor signal transducer and activator of transcription-1 (STAT1) plays a key role in immunity against mycobacterial and viral infections. Activation of the signal transducers and activators of transcription (STAT) pathway is important in fibroblast growth factor (FGF) modulation of chondrocyte proliferation and endochondral bone formation during embryogenesis.
• Synonyms: DKFZp686B04100; ISGF-3; OTTHUMP00000205845; STAT91

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer, Toll-like receptor signaling pathway