Orexin Receptor 1 (HCRTR1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP23376PU-N

Orexin Receptor 1 (HCRTR1) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry with Orexin Receptor polyclonal antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: At 2μg/ml with the appropriate system to detect Orexin Receptor in cells and tissues.
  Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect Orexin Receptor in formalin fixed and paraffin embedded tissues.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal of human Orexin Receptor
• Specificity: This antibody detects Orexin Receptor 1+2 (C-term). No cross reactivity with other proteins.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Gene Name: Homo sapiens hypocretin receptor 1 (HCRTR1)
• Database Link:
  Entrez Gene 25593 RatEntrez Gene 230777 MouseEntrez Gene 3061 Human
• Background: Orexins are endogeneous peptides that activate Orexin Receptor type 1 and type 2, two closely related G-protein coupled receptors. Orexins-A and -B are hypothalamic peptides derived from a precursor called preproorexin and affect the stimulation of food intake. They act on G protein receptors named orexin receptor-1 (OX1R) and orexin receptor-2 (OX2R), respectively.Stimulation of these receptors by orexins causes an increase in intracellular calcium levels in hypothalamic cells in vitro. In vivo, orexins control feeding and may also be involved in modulating sleep-wake cycles and other hypothalamic functions.
• Synonyms: HCRTR1, HCRTR2, Ox1r, Ox2r

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction