SSH3BP1 (ABI1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP23406PU-N

SSH3BP1 (ABI1) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of rat brain tissue lysis using ABI-1 antibody

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: At 1-2μg/ml with the appropriate system to detect Abi-1 in cells and tissues.
  Immunohistochemistry on paraffin sections: At 0.5-1μg/ml to detect Abi-1 in formalin fixed and paraffin embedded tissues.
  Immunohistochemistry on frozen sections: At 0.5-1μg/ml to detect Abi-1 in formalin or acetone fixed tissues. Immunocytochemistry: At 0.5-1μg/ml to detect Abi-1 in acetone fixed cell. Antigen retrieval by Pepsin and Trypsin is required.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human ABI-1
• Specificity: This antibody detects ABI1 / SSH3BP1 (C-term).
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Gene Name: Homo sapiens abl interactor 1 (ABI1), transcript variant 2
• Database Link:
  Entrez Gene 11308 MouseEntrez Gene 79249 RatEntrez Gene 10006 Human
• Background: ABI1 is a human homolog of mouse Abl-interactor-1 (Abi1), mapped on 10p11.2. ABI1 participate in the transduction of signals from Ras to Rac by regulating Rac-specific guanine nucleotide exchange factor (GEF) activities. ABI1 dramatically promoted ABL1-mediated tyrosine phosphorylation of MENA,but not of other substrates. Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins.ABI1 plays a role in the leukemogenesis by translocating to MLL.
• Synonyms: Abl interactor 1, Abelson interactor 1, Abi-1, e3B1, Spectrin binding protein, Nap1-binding protein, Abl-binding protein 4, AblBP4