cyclic GMP Rabbit Polyclonal Antibody

CAT#: AP23444SU-S

cyclic GMP rabbit polyclonal antibody, Serum

Specifications

Product Data

• Applications: R
• Recommended Dilution: RIA
  Antigen binding capacity: Dilutions 1/2000 bound 45-50% of the labelled (radioactive) nucleotide.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Succinyl cGMP- Human Serum Albumin conjugate
• Specificity: Cross-reactivity at 50% displacement:
  cAMP < 0.0005%
  GTP < 0.00001%
  ATP < 0.00001%
• Formulation: State: Serum
  State: Lyophilized Serum
• Reconstitution Method: Restore in aqua bidest to initial volume.
• Background: Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
• Synonyms: cGMP, cyclic guanosine monophosphate