NEI3 (NEIL3) (164-177) Rabbit Polyclonal Antibody

CAT#: AP23595PU-N

NEI3 (NEIL3) (164-177) rabbit polyclonal antibody, Aff - Purified

Product Images

Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from human NEIL3
• Formulation: PBS containing 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens nei like DNA glycosylase 3 (NEIL3)
• Database Link:
  Entrez Gene 55247 Human
• Background: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity.
• Synonyms: Endonuclease VIII-like 3, Nei-like 3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair