BRCC45 (BRE) (9-338) Rabbit Polyclonal Antibody

CAT#: AP23608PU-N

BRCC45 (BRE) (9-338) rabbit polyclonal antibody, Aff - Purified

Product Images

Sample (30 g of whole cell lysate). A:HeLa S3. B:Hep G2. 7.5% SDS PAGE. BRE antibody diluted at 1/500

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  Sample (30 ug of whole cell lysate). A: NIH-3T3. 12% SDS PAGE. BRE antibody. BRE antibody diluted at 1/1000.

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  Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using BRE antibody at 1/200 dilution.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunocytochemistry.
  Immunofluorescence: 1/100 - 1/200.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 9 and 338 of BRE
• Specificity: This antibody reacts to human Brain And Reproductive Organ-expressed Protein (BRE) at aa 9-228.
• Formulation: 0.1 M Tris-glycine, pH 7.0 containing 10% Glycerol and 0.01% Thimerosal
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens brain and reproductive organ-expressed (TNFRSF1A modulator) (BRE), transcript variant 1
• Database Link:
  Entrez Gene 107976 MouseEntrez Gene 362704 RatEntrez Gene 9577 Human
• Background: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
• Synonyms: BRE, BRCC45

Reference Data

• Protein Families: Druggable Genome