FLAP (ALOX5AP) (28-40) Goat Polyclonal Antibody

CAT#: AP23824PU-N

FLAP (ALOX5AP) (28-40) goat polyclonal antibody, Aff - Purified

Product Images

Antibody (0.1 ug/ml) staining of Human U937 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

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  Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/128000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
  Western Blot: 1/128000, 0.1 - 0.3 µg/ml.
• Reactivities: Human, Monkey
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of Human ALOX5AP / FLAP (NP_001620.2)
• Specificity: This antibody recognizes the internal region of ALOX5AP.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilzer and 0.02% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens arachidonate 5-lipoxygenase activating protein (ALOX5AP), transcript variant 2
• Database Link:
  Entrez Gene 241 Human
• Background: Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
  Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
  Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
• Synonyms: MK-886-binding protein

Reference Data

• Protein Families: Druggable Genome, Transmembrane