Chk2 (CHEK2) (514-518) Rabbit Polyclonal Antibody

CAT#: AP26045PU-N

Chk2 (CHEK2) (514-518) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extract from HL60 cells using Chk2 Antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:500 - 1:1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around aa 514~518 derived from Chk2
• Specificity: This antibody detects endogenous levels of total Chk2 protein.
• Formulation: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific peptide
• Gene Name: Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 3
• Database Link:
  Entrez Gene 11200 Human
• Background: The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.
• Synonyms: CHEK2, CHEK-2, CHK-2, RAD53, Cds1
• Note: Molecular weight: 62 kDa

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Stem cell - Pluripotency
• Protein Pathways: Cell cycle, p53 signaling pathway