DR3 (TNFRSF25) Rabbit Polyclonal Antibody

CAT#: AP26338PU-N

DR3 (TNFRSF25) rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 0.5-4 µg/ml.
  Positive Control: Jurkat cell lysate, 3T3 cell lysate, and Rat kidney lysate.
  Immunohistochemistry: 5 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to residues surrounding amino acids 378 of Mouse DR3
• Specificity: The antibody detects a ~48 kDa DR3 in samples from Human, Mouse, and Rat origins.
  Other spceies not tesetd.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified IgG fraction
  Stabilizer: 0.5% BSA, 30% Glycerol
  Preservative: 0.01% Thimerosal
• Concentration: 0.5 mg/ml
• Purification: Affinity Chromatography
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 25 (TNFRSF25), transcript variant 12
• Database Link:
  Entrez Gene 85030 MouseEntrez Gene 500592 RatEntrez Gene 8718 Human
• Background: Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily through interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis through TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen.
• Synonyms: APO3, DDR3, TNFRSF12, WSL, WSL1, Apo-3, AIR, Death receptor 3, LARD, Protein WSL, Protein WSL-1
• Note: Blocking peptide is available separately

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction