DR3 (TNFRSF25) Rabbit Polyclonal Antibody
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Other products for "TNFRSF25"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western blot: 0.5-4 µg/ml. Positive Control: Jurkat cell lysate, 3T3 cell lysate, and Rat kidney lysate. Immunohistochemistry: 5 µg/ml. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to residues surrounding amino acids 378 of Mouse DR3 |
Specificity | The antibody detects a ~48 kDa DR3 in samples from Human, Mouse, and Rat origins. Other spceies not tesetd. |
Formulation | PBS State: Aff - Purified State: Liquid purified IgG fraction Stabilizer: 0.5% BSA, 30% Glycerol Preservative: 0.01% Thimerosal |
Concentration | 0.5 mg/ml |
Purification | Affinity Chromatography |
Gene Name | Homo sapiens tumor necrosis factor receptor superfamily member 25 (TNFRSF25), transcript variant 12 |
Database Link | |
Background | Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily through interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis through TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen. |
Synonyms | APO3, DDR3, TNFRSF12, WSL, WSL1, Apo-3, AIR, Death receptor 3, LARD, Protein WSL, Protein WSL-1 |
Note | Blocking peptide is available separately |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction |
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