STAT1 Rabbit Polyclonal Antibody

CAT#: AP26340PU-N

STAT1 rabbit polyclonal antibody, Aff - Purified

Product Images

: Western blot analysis of Stat1 expression in lysate from 3T3 cells (Lane 1) and rat kidney (Lane 2).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot (0.5-4 µg/ml).
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 672 of rat Stat1
• Specificity: This antibody recognizes both alpha (91 kDa) and beta (84 kDa) subunits of STAT1.
• Formulation: Phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography
• Storage: Upon receipt, store at -20 °C. For long term storage, aliquot and store at -70 °C. Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Gene Name: Homo sapiens signal transducer and activator of transcription 1 (STAT1), transcript variant alpha
• Database Link:
  Entrez Gene 20846 MouseEntrez Gene 25124 RatEntrez Gene 6772 Human
• Background: STATs (signal transducers and activators of transcription) are a family of cytoplamic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signalling peptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6). Stat1, Stat3, Stat5a and Stat5b have wide activation profiles. Stat1 is activated by many different ligands including IFN family (IFN-a, IFN-b, IFN-r, and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF-1), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Stat1 has two forms, the 91 kDa STAT1α and the 84 kDa STAT1β, which are coded by the same gene with splicing variant.
• Synonyms: DKFZp686B04100; ISGF-3; OTTHUMP00000205845; STAT91

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer, Toll-like receptor signaling pathway