IL1 Receptor II (IL1R2) Rabbit Polyclonal Antibody

CAT#: AP26384PU-N

IL1 Receptor II (IL1R2) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: Immunoassays.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Specificity: The antibody reacts specificly with Human Interleukin (IL-1)RII.
  Other species not tested.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purification: Protein A Chromatography
• Database Link:
  Entrez Gene 7850 Human
• Background: The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1RI and IL-1RII) and the IL-1 receptor accessory protein. The IL-1RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signalling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1RI. The decoy IL-1RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts.
• Synonyms: Interleukin-1 receptor type II, IL-1R-2, IL-1R-beta, CDw121b, IL1RB