Telomerase reverse transcriptase (TERT) (597-611) Goat Polyclonal Antibody

CAT#: AP31849PU-N

Telomerase reverse transcriptase (TERT) (597-611) goat polyclonal antibody, Aff - Purified


USD 375.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications ELISA, WB
Recommended Dilution Peptide ELISA: 1/32000 (Detection Limit).
Western blot: 0.3-1 µg/ml. Approx 140kDa band observed in Human Heart and Skeletal Muscle lysates (calculated MW of 127kDa according to NP_937983.2).
Reactivities Human
Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence from the internal region of the protein sequence according to NP_937983.2; NP_001180305.1.
Specificity This antibody recognizes TERT (597-611).
It is expected to recognize both reported isoforms (NP_937983.2, (NP_001180305.1).
Formulation Tris buffered saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens telomerase reverse transcriptase (TERT), transcript variant 2
Background Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
Synonyms Telomerase reverse transcriptase, HEST2, EST2, TCS1, TRT
Reference Data
Protein Families Druggable Genome

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