Stromal interaction molecule 1 (STIM1) (N-term) Sheep Polyclonal Antibody

CAT#: AP33389PU-N

Stromal interaction molecule 1 (STIM1) (N-term) sheep polyclonal antibody, Aff - Purified

Product Images

Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 µg/ml.
• Reactivities: Human
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GOK / STIM1 antibody was raised against stim 1 affinity purified antibody was prepared from whole Sheep serum produced by repeated immunizations with a synthetic peptide near the N-terminus of Human Stim 1.
• Specificity: Recognizes GOK / STIM1 at N-terminus
• Formulation: 0.02M Potassium Phosphate, 0.15M Sodium Chloride, pH 7.2, 50% Glycerol
  State: Aff - Purified
  State: Liquid (sterile filtered) purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 6786 Human
• Background: In T lymphocytes, the sole pathway for Ca⁺⁺ entry following antigen-receptor binding is through store-operated Ca⁺⁺-release-activated Ca⁺⁺ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca⁺⁺ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca⁺⁺ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca⁺⁺ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca⁺⁺ entry. At least two isoforms of STIM1 are known to exist.
• Synonyms: Stromal interaction molecule 1