Centaurin gamma 1 (AGAP2) (C-term) Rabbit Polyclonal Antibody
CAT#: AP50861PU-N
Centaurin gamma 1 (AGAP2) (C-term) rabbit polyclonal antibody, Aff - Purified
Other products for "AGAP2"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | ELISA: 1/1000. Western blot: 1/100 - 1/500. |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1 |
Specificity | This antibody reacts to CENTG1. |
Formulation | PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) sodium azide |
Concentration | lot specific |
Purification | Affinity chromatography on Protein A |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | 124674 Da |
Gene Name | Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 1 |
Database Link | |
Background | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. |
Synonyms | Centaurin-gamma-1, KIAA0167, GGAP2, PIKE |
Reference Data | |
Protein Pathways | Endocytosis |
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