COP (CARD16) (N-term) Rabbit Polyclonal Antibody
Other products for "CARD16"
Specifications
Product Data | |
Applications | FC, WB |
Recommended Dilution | Western blot: 1/1000. Flow Cytometry: 1/10 - 1/50. |
Reactivities | Human |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COP1 |
Specificity | This antibody reacts to COP1. |
Formulation | PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) sodium azide |
Concentration | lot specific |
Purification | Chromatography on Protein A, followed by peptide affinity purification. |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | 22625 Da |
Gene Name | Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 1 |
Database Link | |
Background | Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. |
Synonyms | Caspase-1 inhibitor COP, PSEUDO-ICE |
Reference Data |
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