RFXANK (Center) Rabbit Polyclonal Antibody

CAT#: AP53645PU-N

RFXANK (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of ANKRA1 / RFXANK Antibody in WiDr cell line lysates (35ug/lane). This demonstrates the RFXANK antibody detected the RFXANK protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 93-123 amino acids from the Central region of human RFXANK.
• Specificity: This antibody recognizes Human ANKRA1 / RFXANK (Center).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens regulatory factor X associated ankyrin containing protein (RFXANK), transcript variant 1
• Database Link:
  Entrez Gene 8625 Human
• Background: Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.
• Synonyms: RFXB
• Note: Molecular Weight: 28102 Da

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Antigen processing and presentation, Primary immunodeficiency