RPGR (C-term) Rabbit Polyclonal Antibody

CAT#: AP53704PU-N

RPGR (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

RPGR Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane). This demonstrates the RPGR antibody detected the RPGR protein (arrow).

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  RPGR Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RPGR Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/1000.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 744-772 amino acids from the C-terminal region of Human RPGR
• Specificity: This antibody recognizes RPGR.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) Sodium Azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A followed by peptide afffiniy purification.
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 113387 Da
• Gene Name: Homo sapiens retinitis pigmentosa GTPase regulator (RPGR), transcript variant A
• Database Link:
  Entrez Gene 6103 Human
• Background: This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.
• Synonyms: RP3, XLRP3

Reference Data

• Protein Families: Druggable Genome