ELOC (C-term) Rabbit Polyclonal Antibody

CAT#: AP54199PU-N

ELOC (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

TCEB1 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35 ug/lane). This demonstrates the TCEB1 antibody detected the TCEB1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:1;000.
  Western blot: 1:100~500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 68-98 amino acids from the C-terminal region of human TCEB1
• Specificity: This antibody detectsTCEB1 (C-term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Storage: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant 2
• Database Link:
  Entrez Gene 6921 Human
• Background:
  
  

  
  

  
  

  
  

  This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

  
  

  
  

  
  

  
  
  
  
• Synonyms: Elongin 15 kDa subunit, Elongin-C, Elongin C, EloC
• Note: Molecular Weight: 12473 Da

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis