USP7 (Center) Rabbit Polyclonal Antibody
Other products for "USP7"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | ELISA: 1:1;000. Western blot: 1:100~500. |
Reactivities | Human |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 319-348 amino acids from the Central region of human USP7 |
Specificity | This antibody detects USP7 / HAUSP (Center). |
Formulation | PBS with 0.09% (W/V) sodium azide State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein A column followed by peptide affinity purification |
Storage | Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens ubiquitin specific peptidase 7 (herpes virus-associated) (USP7), transcript variant 1 |
Database Link | |
Background | Hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. Deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. |
Synonyms | Ubiquitin carboxyl-terminal hydrolase 7 |
Note | Molecular Weight: 128302 Da |
Reference Data | |
Protein Families | Druggable Genome, Protease |
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