VEGF Receptor 2 (KDR) Rabbit Polyclonal Antibody

CAT#: AP54510PU-N

VEGF Receptor 2 (KDR) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of VGFR2 Antibody (AP54510PU-N) in mouse cerebellum tissue lysates (35 g/lane). VGFR2 (arrow) was detected using the purified Pab.

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  Formalin-fixed and paraffin-embedded human breast carcinoma reacted with VGFR2 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1:1;000.
  Western blot: 1:50~100.
  Immunohistochemistry on paraffin sections: 1:50~100.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Specificity: This antibody detects CD309 / VEGFR-2 / Flk-1.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Storage: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR)
• Database Link:
  Entrez Gene 3791 Human
• Background: VEGF is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.
• Synonyms: VEGFR2, FLK1, KDR, VEGF Receptor 2
• Note: Molecular Weight: 149256 Da

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway